Urinary Tract Physiological Genomics Laboratory
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We are using knockout and transgenic animal models to correlate morphological changes with gene regulation. The following projects are being developed:


  1. Inflammation
    1. Functional Genomics of bladder inflammation
    2. Role of mast cells and sensory nerves in inflammation
    3. Role of substance P (NK1) receptors in inflammation
    4. Role of protease-activated receptors (PARs) in inflammation
    5. Role of NF-kB inhibitors on the inflammatory cascade


  2. Infection
    1. E.coli LPS induced gene-regulation
    2. Enterococcus -Urothelial Interaction In Bladder Inflammation
    3. BCG-induced bladder inflammation


  3. Bladder Cancer
    1. BCG-induced bladder gene expression. SSH and cDNA array




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